Bio-product Molecule Design
and Optimization Platform
Molecule Design Molecule Optimization
Introduction
The AlfaDAX system enables customers to quickly screen and modify protein candidates before they enter the CMC stage, reducing trial and error costs and accelerating the development of new drugs.
Advantages
5 mins
Assessment report
5 days
Optimization report
Optimized 3 to 1 package
（Humanization +Affinity +
Developability）
in silico work
instead of wet lab work
Molecule Design
The predictions showed 100% consistency
with the final experimental validation.
Monoclonal Antibody Affnity Increased 29-Fold
Relationship Between Conformation
and Activity
Relationship Between Conformation and Activity
Molecule Optimization
Affinity Enhancement
Case1: Monoclonal Antibody
Affinity Increased 29-Fold
Case1:Monoclonal Antibody Affinity Increased 29-Fold
Case2: 43-Fold Affinity Improvement
with Multi-Metric Validation
Relationship Between Conformation and Activity
Case3: Nanobody Affinity Increased
19.6-Fold
Case3:Nanobody Affinity Increased 19.6-Fold
Humanization Enhancement
Case1: Triple Optimization of Monoclonal
Antibody Humanization
Case1:Triple Optimization of Monoclonal Antibody Humanization
Case2: Breakthrough in Challenging
Monoclonal Antibody Humanization
Case2: Breakthrough in Challenging Monoclonal Antibody Humanization
Case3: Nanobody Humanization
Enhancement
Case3:Nanobody Humanization Enhancement
Affinity + Humanization + Developability Optimization
Case 1: 77-Fold Affinity Improvement with
Concurrent Functional and Stability Enhancement
Case 1: 77-Fold Affinity Improvement with Concurrent Functional and Stability Enhancement
Case 2: Nanobody Optimization Achieving
Both High Affinity and High Humanization
(94.32% Germline Identity)
Case 2:Nanobody Optimization Achieving Both High Affinity and High Humanization (94.32% Germline Identity)
Case 3: Multidimensional Optimization of
a Bispecific Antibody
Case 3: Multidimensional Optimization of a Bispecific Antibody
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