Fluorescent Site-Specific Integration
Cell Line Development Kit
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Great Bay Bio developed a proprietary AlfaCell platform that applies Site-Specific Integration (SSI) technology and Al-enabled cell selection to accurately insert the target genes into specific “hot spot” within the genome of a host cell line, AlfaCell platform significantly reduces time, manpower, and cost that are associated with the development of high-performance mammalian cell lines.
Case Study
Proven High-Titer Expression Across 100+ Molecules
● mAb: Up to 15 g/L
● BsAb: Up to 12 g/L, 4-chain BsAb up to 8.3 g/L (with 88% correct pairing)
● Nanobody: Up to 13.1 g/L
● BsAb: Up to 12 g/L, 4-chain BsAb up to 8.3 g/L (with 88% correct pairing)
● Nanobody: Up to 13.1 g/L
Scalable High-Titer Expression with Reliable Correct Pairing
Across multiple antibody formats, AlfaCell delivers robust expression and assembly, achieving titers from 5.5 to 16.2 g/L with high correct pairing (84–100%) across IgG, diverse bispecifics, and nanobody constructs.
